For your eligible patients
with NVAF & VTE:

What is LIXIANA® indicated for?

LIXIANA® is indicated for:1 prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation (NVAF) with one or more risk factors, such as congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischaemic attack (TIA)

Superior reduction
in major bleeding

vs. well-managed warfarin2

Consistent efficacy and safety profile

even when used with dose reduction2

Once-daily dosing with or without food

in NVAF1

In patients with NVAF and high CrCl, there is a trend towards decreasing efficacy with increasing CrCl for edoxaban vs well-managed warfarin, therefore careful evaluation of thromboembolic and bleeding risk is necessary before initiation.

LIXIANA® demonstrated superior reduction in major bleeding vs. well managed warfarin2*

In the safety-on-treatment population

the annualised rate of major bleeding events with once-daily LIXIANA® 
vs. well-controlled warfarin was: 2.75% vs 3.43%2*

HR 0.80; 95% CI, 0.71 to 0.91; P<0.001

Read about the ENGAGE AF-TIMI 48 trial. The longest DOAC trial to date in NVAF

LIXIANA® – simple and convenient once-daily dosing
in NVAF3

60 mg Standard dose

The recommended dose of LIXIANA® is 60 mg in a 
once-daily tablet. It can be taken with water, with or without food. To aid compliance, patients should be encouraged to take their dose at the same time 
every day.

30 mg Reduced dose

A dose of 30 mg once daily is required for certain patients who fall into specific sub-groups.

Can be taken with or without food1

Not significantly affected by CYP450 inducers/inhibitors
(<10% is metabolised by CYP3A4/5)1

Rapid onset of anticoagulant therapeutic effect
(1-2 hours)1

No routine anticoagulation level monitoring required1

Lactose not listed as an excipient3**

In patients with NVAF and high CrCl, there is a trend towards decreasing efficacy with increasing CrCl for edoxaban vs well-managed warfarin, therefore careful evaluation of thromboembolic and bleeding risk is necessary before initiation.

Risk factors

Recommended for patients with one or more of the following factors that increase risks of bleeding:1

Renal impairment
(CrCl 15−50 ml/min)

Low body weight
(≤60 kg)

Concomitant use of potent P-gp inhibitors
(dronedarone, erythromycin, ketoconazole, ciclosporin)

For more information on how to use LIXIANA® please download our practical guide

Footnotes

* The primary safety endpoint of ENGAGE AF-TIMI 48 was the incidence of ajudicated major bleeding2, defined by the International Society of Thrombosis and Haemostasis (ISTH) as (i) fatal bleeding; and/or (ii) symptomatic bleeding in critical area or organ, such as intracranial, intraspinal, intraocular, retroperitoneal, intraarticular, pericardial, or intramuscular with compartment syndrome, and/or (iii) bleeding causing a fall in haemoglobin level of 2.0 g/dl or more, or leading to transfusion of two or more units of whole blood or red cells.4

** We cannot guarantee that there has been no contact with lactose during manufacture. Use with caution in patients that have had severe anaphylaxis with lactose products.3

CrCl, creatinine clearance; CYP, cytochrome P450; DOAC, direct oral anticoagulant; P-gp, P‑glycoprotein; VTE, venous thromboembolism.